GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4663866 | 1 | rs34897410 | chr2:239182123 | LOC151174 | chr2:239133754-239140318:- | 0.45 | 4.55 | 7.1E-6 | Irritable bowel syndrome |
| BLCA | cis | rs12908161 | 1 | rs34900908 | chr15:85257599 | LOC388152 | chr15:84867600-84898920:- | -0.24 | -4.11 | 4.83E-5 | Schizophrenia |
| BLCA | cis | rs7927771 | 1 | rs34910028 | chr11:47758449 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.62 | 3.73E-8 | Subjective well-being |
| BLCA | cis | rs2243480 | 1 | rs34933526 | chr7:65383199 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.47 | 1.02E-5 | Diabetic kidney disease |
| BLCA | cis | rs11622475 | 1 | rs34964872 | chr14:104448435 | TDRD9 | chr14:104394817-104519002:+ | 0.34 | 5.42 | 1.04E-7 | Bipolar disorder |
| BLCA | cis | rs2243480 | 1 | rs34970380 | chr7:65431493 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.47 | 1.05E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs34974928 | chr7:65364006 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.38 | 1.53E-5 | Diabetic kidney disease |
| BLCA | cis | rs7655841 | 1 | rs35006492 | chr4:129878342 | C4orf33 | chr4:130014829-130033842:+ | 0.32 | 4.97 | 1.01E-6 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs9371538 | 1 | rs35025342 | chr6:151876661 | C6orf97 | chr6:151815175-151942327:+ | 0.28 | 4.07 | 5.63E-5 | Bone mineral density (spine) |
| BLCA | cis | rs2243480 | 1 | rs35046236 | chr7:65408613 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.47 | 1.02E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs35058610 | chr7:65390925 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.48 | 9.9E-6 | Diabetic kidney disease |
| BLCA | cis | rs4237643 | 1 | rs35060985 | chr11:43693110 | HSD17B12 | chr11:43702143-43878160:+ | -0.42 | -6.97 | 1.38E-11 | Forced vital capacity |
| BLCA | cis | rs12748152 | 1 | rs35108146 | chr1:27248440 | GPN2 | chr1:27205873-27216869:- | 0.47 | 3.96 | 8.9E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BLCA | cis | rs35141484 | 1 | rs35141484 | chr4:39088341 | PDS5A | chr4:39824484-39979576:- | -0.56 | -4.1 | 5.03E-5 | Asthma (childhood onset) |
| BLCA | cis | rs35141484 | 1 | rs35141484 | chr4:39088341 | RFC1 | chr4:39289076-39367995:- | -0.5 | -4 | 7.54E-5 | Asthma (childhood onset) |